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In this episode of The Healthspan Collective, host Nicole Doran sits down with Chris Mirabile, founder and CEO of Novos Labs and author of Slow My Age, to explore the science and nuance behind modern longevity. After experiencing a seizure at 16 that led to the discovery of a brain tumor, Chris became deeply focused on disease prevention and understanding aging as the primary driver of chronic illness.
Now a leading voice in the longevity space, Chris breaks down the 12 hallmarks of aging framework that informs Novos Core, a supplement designed to target multiple aging pathways at once. The conversation explores what the current research actually shows, including reductions in oxidative DNA damage, effects on cellular senescence, and improvements in cardiovascular biomarkers from randomized human trials.
Nicole and Chris also discuss biological age testing, including DunedinPACE and GrimAge clocks, the realities of longevity marketing, and why extreme lifespan claims often miss the point. They unpack the protein paradox, mTOR and AMPK cycling, sex differences in lifespan, hormone signaling, and how to balance long term healthspan with quality of life. Chris also shares his personal longevity protocol, including strength training, time restricted eating, seafood focused nutrition, high polyphenol olive oil, targeted supplementation, and sleep as a foundational pillar.
This episode offers a grounded, evidence informed look at what actually moves the needle in longevity and what simply fuels the hype.
What We Cover:
🧠 The seizure and brain tumor that reshaped Chris’s life
🧬 The 12 hallmarks of aging and how they inform supplement design
📊 Novos Core research on DNA damage, senescence, and cardiovascular health
🩸 Biological age testing explained including DunedinPACE and GrimAge
🥩 The protein paradox, mTOR, AMPK, and amino acid considerations
⚖️ Balancing optimization with quality of life
😴 Why sleep remains one of the most underrated longevity tools
Chapters:
00:00 From Fitness Focus to Longevity Mindset
01:57 The Seizure That Changed Everything
05:08 Lifestyle Discipline, Sleep, and the 80 20 Rule
12:06 How Novos Core Was Built
18:03 Targeting All 12 Hallmarks of Aging
27:21 Biological Age Tests Explained
36:23 Longevity Marketing and Extreme Lifespan Claims
40:13 Hormones and Sex Differences in Lifespan
43:13 The Protein Paradox and Protein Timing
49:21 Chris’s Personal Longevity Stack
56:08 Why Health Misinformation Spreads
01:06:50 Cancer Caution and Rapid Fire
